Invitrogen™ DR4 Monoclonal Antibody (DR-4-02), FITC

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA119757

Catalog No. PIMA119757

Description

This antibody recognizes an extracellular epitope of TRAIL-R1 (DR4), a human death receptor 4 expressed in most human tissues (spleen, peripheral blood leucocytes, thymus) and in a variety of tumor-derived cell lines.

TRAIL-R1 (CD261, DR4) is a type I transmembrane protein, also called TRAIL receptor 1. The ligand for this DR4 death receptor has been identified and termed TRAIL, which is a member of the TNF family. DR4, as many other receptors (Fas, TNFR1, etc.), mediates apoptosis and NF kappaB activation in many cells and tissues. Apoptosis, a programmed cell death, is a operating process in normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by coupled of certain cytokines (TNF family - TNF, Fas ligand) and their death domain containing receptors (TNFR1, Fas receptor).

Specifications

• Antigen: DR4
• Classification: Monoclonal
• Concentration: 0.1 mg/mL
• Formulation: PBS with 0.2% BSA and 15mM sodium azide; pH 7.4
• Gene Accession No.: O00220
• Gene Symbols: TNFRSF10A
• Immunogen: Fusion protein containing the extracellular part of TRAIL-R1 and the constant part of the heavy chain of the human IgG1.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Flow Cytometry
• Clone: DR-4-02
• Conjugate: FITC
• Gene: TNFRSF10A
• Gene Alias: APO2; CD261; cytotoxic TRAIL receptor; death receptor 4; DR4; MGC9365; sCD261; soluble CD261; soluble TRAIL; sTRAIL; TNF receptor superfamily member 10a; TNF-related apoptosis-inducing ligand receptor 1; TNFRSF10A; TRAIL R1; TRAIL receptor 1; TRAILR1; TRAIL-R1; TRAILR-1; tumor necrosis factor receptor superfamily member 10A; tumor necrosis factor receptor superfamily member 10a variant 2; tumor necrosis factor receptor superfamily, member 10a
• Host Species: Mouse
• Purification Method: Size-exclusion Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 8797
• Content And Storage: 4°C, store in dark, DO NOT FREEZE!
• Form: Liquid