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Invitrogen™ DR4 Polyclonal Antibody
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Catalog No. PIPA5120175
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100 μL
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PIPA5120175 100 μL
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Catalog No. PIPA5120175 Supplier Invitrogen™ Supplier No. PA5120175
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Description

Rabbit Polyclonal Antibody

Positive test controls include: K-562, SW480, MCF7, HeLa, DU145, Mouse lung, Rat lung. The target is usually found in the following locations: Membrane, Single-pass type I membrane protein. Immunogen sequence: GGDPKCMDRV CFWRLGLLRG PGAEDNAHNE ILSNADSLST FVSEQQMESQ EPADLTGVTV QSPGEAQCLL GPAEAEGSQR RRLLVPANGA DPTETLMLFF DKFANIVPFD SWDQLMRQLD LTKNEIDVVR AGTAGPGDAL YAMLMKWVNK TGRNASIHTL LDALERMEER HAREKIQDLL VDSGKFIYLE DGTGSAVSLE.

TRAIL-R1 (CD261, DR4) is a type I transmembrane protein, also called TRAIL receptor 1. The ligand for this DR4 death receptor has been identified and termed TRAIL, which is a member of the TNF family. DR4, as many other receptors (Fas, TNFR1, etc.), mediates apoptosis and NF kappaB activation in many cells and tissues. Apoptosis, a programmed cell death, is a operating process in normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by coupled of certain cytokines (TNF family - TNF, Fas ligand) and their death domain containing receptors (TNFR1, Fas receptor).
TRUSTED_SUSTAINABILITY

Specifications

Antigen DR4
Applications ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1.39 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene TNFRSF10A
Gene Accession No. O00220
Gene Alias APO2; CD261; cytotoxic TRAIL receptor; death receptor 4; DR4; MGC9365; sCD261; soluble CD261; soluble TRAIL; sTRAIL; TNF receptor superfamily member 10a; TNF-related apoptosis-inducing ligand receptor 1; TNFRSF10A; TRAIL R1; TRAIL receptor 1; TRAILR1; TRAIL-R1; TRAILR-1; tumor necrosis factor receptor superfamily member 10A; tumor necrosis factor receptor superfamily member 10a variant 2; tumor necrosis factor receptor superfamily, member 10a
Gene Symbols TNFRSF10A
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 269-468 of human TNFRSF10A (NP_003835.3).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 8797
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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