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Invitrogen™ DR4 Polyclonal Antibody
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Catalog No. PIPA130795
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100 μg
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PIPA130795 100 μg
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Catalog No. PIPA130795 Supplier Invitrogen™ Supplier No. PA130795
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: Jurkat Cell Lysate(GTX27899), HepG2 Cell Lysate(GTX27900), Human Spleen Tissue Slide. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

TRAIL-R1 (CD261, DR4) is a type I transmembrane protein, also called TRAIL receptor 1. The ligand for this DR4 death receptor has been identified and termed TRAIL, which is a member of the TNF family. DR4, as many other receptors (Fas, TNFR1, etc.), mediates apoptosis and NF kappaB activation in many cells and tissues. Apoptosis, a programmed cell death, is a operating process in normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by coupled of certain cytokines (TNF family - TNF, Fas ligand) and their death domain containing receptors (TNFR1, Fas receptor).
TRUSTED_SUSTAINABILITY

Specifications

Antigen DR4
Applications ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene TNFRSF10A
Gene Accession No. O00220
Gene Alias APO2; CD261; cytotoxic TRAIL receptor; death receptor 4; DR4; MGC9365; sCD261; soluble CD261; soluble TRAIL; sTRAIL; TNF receptor superfamily member 10a; TNF-related apoptosis-inducing ligand receptor 1; TNFRSF10A; TRAIL R1; TRAIL receptor 1; TRAILR1; TRAIL-R1; TRAILR-1; tumor necrosis factor receptor superfamily member 10A; tumor necrosis factor receptor superfamily member 10a variant 2; tumor necrosis factor receptor superfamily, member 10a
Gene Symbols TNFRSF10A
Host Species Rabbit
Immunogen Synthetic peptide, corresponding to amino acids 427-445 of Human DR4.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 8797
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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