Invitrogen™ DR6 Monoclonal Antibody (03)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA531265

Catalog No. PIMA531265

Description

This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%). This antibody has specificity for Human TNFRSF21/DR6.

DR6 is widely expressed in human tissues and cell lines. The ligand for DR6 has not been identified. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNF-R1 and Fas. Several novel death receptors including DR3, DR4, and DR5 were recently identified. A new death domain containing receptor in the TNFR family was cloned recently and termed DR6 for death receptor-6. Like TNF-R1, DR6 interacts with death domain containing adapter molecule TRADD. Overexpression of DR6 induces apoptosis and activates NF-kappa-B and JNK.

Specifications

• Antigen: DR6
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with no preservative
• Gene Accession No.: O75509
• Gene Symbols: TNFRSF21
• Immunogen: Recombinant Human TNFRSF21/DR6 Protein (Met1-Leu350).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: ELISA
• Clone: 03
• Conjugate: Unconjugated
• Gene: TNFRSF21
• Gene Alias: AA959878; BM-018; CD358; Death receptor 6; Death receptor-6; DR6; MGC31965; R74815; sCD358; sDR6; soluble CD358; soluble DR6; TNF receptor superfamily member 21; TNFR-related death receptor 6; TNFR-related death receptor-6; Tnfrsf21; TR7; Tumor necrosis factor receptor superfamily member 21; tumor necrosis factor receptor superfamily, member 21; UNQ437/PRO868
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 27242
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid