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Invitrogen™ DR6 Polyclonal Antibody
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Catalog No. PIPA519930
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100 μg
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Catalog No. Quantity
PIPA519930 100 μg
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Catalog No. PIPA519930 Supplier Invitrogen™ Supplier No. PA519930
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Description

Rabbit Polyclonal Antibody

In Western blot applications, this antibody detects a band at ~68kDa. A suggested positive control is Hela cell lysate. PA5-19930 can be used with blocking peptide PEP-0055.

DR6 is widely expressed in human tissues and cell lines. The ligand for DR6 has not been identified. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNF-R1 and Fas. Several novel death receptors including DR3, DR4, and DR5 were recently identified. A new death domain containing receptor in the TNFR family was cloned recently and termed DR6 for death receptor-6. Like TNF-R1, DR6 interacts with death domain containing adapter molecule TRADD. Overexpression of DR6 induces apoptosis and activates NF-kappa-B and JNK.
TRUSTED_SUSTAINABILITY

Specifications

Antigen DR6
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene TNFRSF21
Gene Accession No. O75509
Gene Alias AA959878; BM-018; CD358; Death receptor 6; Death receptor-6; DR6; MGC31965; R74815; sCD358; sDR6; soluble CD358; soluble DR6; TNF receptor superfamily member 21; TNFR-related death receptor 6; TNFR-related death receptor-6; Tnfrsf21; TR7; Tumor necrosis factor receptor superfamily member 21; tumor necrosis factor receptor superfamily, member 21; UNQ437/PRO868
Gene Symbols TNFRSF21
Host Species Rabbit
Immunogen A peptide corresponding to amino acids 42 to 56 of human DR6 precursor.
Purification Method Ion-exchange chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 27242
Target Species Human
Content And Storage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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