Invitrogen™ DREF Monoclonal Antibody (OTI2E5)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA526034

Catalog No. PIMA526034

Description

DREF Monoclonal Antibody for Western Blot, IHC (P), Flow

ZBED1, also known as DREF, is the human homolog of the Drosophila protein DREF, a transcriptional regulatory factor required for expression of genes involved in DNA replication and cell proliferation. RNA interference (RNAi) experiments targeting ZBED1 RNA resulted in the inhibition of S phase entry and reduction of histone H1 mRNA in HeLa cells, suggesting that ZBED1 also plays a role in cell proliferation in human cells. At least 22 ribosomal proteins (RPs) possess ZBED1 binding sites in their promoters; anti-ZBED1 RNAi also resulted in decreased RP gene expression. Immunoprecipitation analyses have shown that ZBED1 self-associates in vivo via a carboxyl-terminal hATC domain, and this self-association is required for nuclear localization and DNA binding.

Specifications

• Antigen: DREF
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: O96006
• Gene Symbols: ZBED1
• Immunogen: Full length human recombinant protein of ZBED1 produced in HEK293T cell.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2a

• Applications: Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
• Clone: OTI2E5
• Conjugate: Unconjugated
• Gene: ZBED1
• Gene Alias: Ac-like transposable element; ALTE; BED-type zinc finger domain-containing protein 1; DNA replication-related element binding factor; DREF; dREF homolog; hDREF; KIAA0785; Putative Ac-like transposable element; TRAMP; ZBED1; Zinc finger BED domain-containing protein 1; zinc finger BED-type containing 1; zinc finger, BED-type containing 1
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 9189
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid