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Invitrogen™ DRG1 Polyclonal Antibody
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Catalog No. PIPA551540
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100 μL
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PIPA551540 100 μL
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Catalog No. PIPA551540 Supplier Invitrogen™ Supplier No. PA551540
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: ELEGFGIRLN SKPPNIGFKK KDKGGINLTA TCPQSELDAE TVKSILAEYK IHNADVTLRS DATADDLIDV VEGNRVYIPC IYVLNKIDQI SIEELDIIYK VPHCVPISAH HRWNFDDLLE KIWDYLKLVR IYTKPKGQLP DYT Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 100%.

Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP (PubMed:29915238, PubMed:23711155). Appears to have an intrinsic GTPase activity that is stimulated by ZC3H15/DFRP1 binding likely by increasing the affinity for the potassium ions (PubMed:23711155). When hydroxylated at C-3 of 'Lys-22' by JMJD7, may bind to RNA and play a role in translation (PubMed:19819225, PubMed:29915238). Binds to microtubules and promotes microtubule polymerization and stability that are required for mitotic spindle assembly during prophase to anaphase transition. GTPase activity is not necessary for these microtubule-related functions (PubMed:28855639). [UniProt].
TRUSTED_SUSTAINABILITY

Specifications

Antigen DRG1
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene DRG1
Gene Accession No. P32233, Q9Y295
Gene Alias AA408859; AI132520; developmentally regulated GTP binding protein 1; developmentally regulated GTP-binding protein 1; developmentally-regulated GTP-binding protein 1; Drg; Drg1; DRG-1; GTP-binding protein; NEDD3; NEDD-3; neural precursor cell expressed developmentally down-regulated protein 3; neural precursor cell expressed, developmentally down-regulated 3; TRAFAC GTPase DRG1; Translation factor GTPase DRG1
Gene Symbols DRG1
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human DRG1. Recombinant protein control fragment (Product #RP-91361).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 13494, 305470, 4733
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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