Invitrogen™ CRMP1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA520176

Catalog No. PIPA520176

Description

A suggested positive control is Caco-2 cell lysate. PA5-20176 can be used with blocking peptide PEP-0293.

Collapsin-response mediator proteins (CRMPs) are highly expressed in the developing brain where they play major roles in axonal outgrowth, neurite differentiation, and apoptosis. Their continued expression in areas of high synaptic remodeling such as the cerebellum, hippocampus, and the olfactory system suggests that these proteins may also be involved in adult brain plasticity. CRMP-1 was initially identified as a dihydro-pyrimidinase expressed exclusively in brain; later studies have shown that it is involved with neurotrophin (NT) 3-induced neurite formation and outgrowth. CRMP-1 localization switches from axonal to somatodendritic when neurons reach functional maturity, suggesting that it is involved in early neuronal differentiation as well as in later processes related to the survival or death of the newly generated neurons.

Specifications

• Antigen: CRMP1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CRMP1
• Gene Alias: Collapsin response mediator protein 1; Crmp1; CRMP-1; dihydropyrimidinase-like 1; dihydropyrimidinase-related protein 1; Dpysl1; DRP1; DRP-1; Ulip3; ULIP-3; Unc-33-like phosphoprotein 3
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 12933, 1400, 25415
• Content And Storage: Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
• Form: Liquid

• Applications: Immunohistochemistry, Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: P97427, Q14194, Q62950
• Gene Symbols: CRMP1
• Immunogen: A 16 amino acid peptide from near the center of human CRMP1.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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