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Tocris Bioscience™ DSPE-PEG 2000 Maleimide
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Catalog No. 794710
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10 mg
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79-471-0 10 mg
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Catalog No. 79-471-0 Supplier Tocris Bioscience™ Supplier No. 7947/10
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Description

PEGylated DSPE with a maleimide reactive group

DSPE-PEG (2000) maleimide is a functionalized phospholipid-polymer conjugate. It comprises a 1,2-distearoyl-sn-glycero-PE (DSPE) covalently coupled to a linear polyethylene glycol (Mr 2000) with a maleimide-terminated end. It is used to synthesize antibody-coupled PEG (2000)-DSPE micelles that can be transferred into liposomes to generate immunoliposomes. DSPE-PEG (2000) maleimide can also be incorporated into the outer membrane of lipid nanoparticles (LNPs) for further bioconjugation. It is used in antibody-targeted LNP-mRNA systems to generate transient antifibrotic chimeric antigen receptor (CAR) T cells in vivo.

Specifications

Chemical Name or Material 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[maleimide(polyethylene glycol-2000)]
Quantity 10 mg
Target Lipid Nanoparticles
Molecular Formula (C2H4O)nC51H91N3O13P.NH4 or Na
Purity 90%
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