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Tocris Bioscience™ DSRM-3716
GREENER_CHOICE

Catalog No. 741450
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Quantity:
50 mg
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Potent and reversible SARM1 NAD hydrolase inhibitor

DSRM-3716 is a potent, reversible inhibitor of SARM1 NAD(+) hydrolase (IC50 = 75 nM), which displays selectivity for SARM1 over related enzymes NAMPT and NMNAT and a panel of receptors and transporters. In vitro, DSRM-3716 decreases cyclic adenosine diphosphate ribose (cADPR) levels in mouse dorsal root ganglia (DRG) neurons, and protects mouse DRG and iPSC-derived human motor neurons against axonal degeneration. In axons with rotenone (Cat. No. 3616)-induced mitochondrial injury, DSRM-3716 rescues axons displaying indicators of degeneration.

Specifications

Chemical Name or Material 5-Iodoisoquinoline
CAS 58142-99-7
Quantity 50 mg
Target Hydrolase Inhibitors
Molecular Formula C9H6IN
Purity 0.98
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