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Tocris Bioscience™ DSRM-3716

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Quantity:
50 mg
Description
DSRM-3716 is a potent, reversible inhibitor of SARM1 NAD(+) hydrolase (IC50 = 75 nM), which displays selectivity for SARM1 over related enzymes NAMPT and NMNAT and a panel of receptors and transporters. In vitro, DSRM-3716 decreases cyclic adenosine diphosphate ribose (cADPR) levels in mouse dorsal root ganglia (DRG) neurons, and protects mouse DRG and iPSC-derived human motor neurons against axonal degeneration. In axons with rotenone (Cat. No. 3616)-induced mitochondrial injury, DSRM-3716 rescues axons displaying indicators of degeneration.
Specifications
Specifications
Chemical Name or Material | 5-Iodoisoquinoline |
CAS | 58142-99-7 |
Quantity | 50 mg |
Target | Hydrolase Inhibitors |
Molecular Formula | C9H6IN |
Purity | 0.98 |
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