Tocris Bioscience™ dTAG-7

Catalog No.	Quantity
69-125	5 mg

Catalog No. 69-125 Supplier Tocris Bioscience™ Supplier No. 6912/5

Description

First generation Degrader for mutant FKBP12F36V fusion proteins; useful alternative to genetic methods for target validation

dTAG-7 is a first generation Degrader for mutant FKBP12F36V fusion proteins. Comprises a ligand selective for F36V single-point mutated FKBP12, a linker and a cereblon-binding ligand. Application of dTAG-7 induces rapid, reversible and selective degradation of FKBP12F36V fusion proteins in vitro and in vivo. dTAG is generalizable to a range of fusion proteins; useful as an alternative to genetic methods for target validation. See also dTAG-13 .

FKBP12F36V can be expressed as a fusion with a target protein of interest using genome engineering techniques, via transgene expression or CRISPR-mediated locus-specific knock-in. Custom knock-in cell lines for the dTAG and aTAG platforms are available from our sister brand R&D Systems . Email TPD@bio-techne.com to enquire.

Plasmid vectors for the lentiviral expression and CRISPR-mediated knock-in of FKBP12F36V are available from Addgene.

Specifications

• Chemical Name or Material: (1 R)-3-(3,4-Dimethoxyphenyl)-1-(2-((19-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)-2,18-dioxo-7,10,13-trioxa-3,17-diazanonadecyl)oxy)phenyl)propyl (2 S)-1-(-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate
• CAS: 2064175-32-0
• Quantity: 5 mg
• Target: TAG Degradation Platforms
• Molecular Formula: C₆₃H₇₉N₅O₁₉
• Purity: 98%