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DTL/CDT2 Rabbit anti-Human, Polyclonal, Bethyl Laboratories

Catalog No. 501558858
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50-155-8858 10 μL
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Catalog No. 50-155-8858 Supplier Bethyl Laboratories, Inc Supplier No. A300947AT
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Description

Rabbit Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt. Application Note: For IHC, epitope retrieval with Tris-EDTA pH 9.0 is recommended for FFPE tissue sections.

Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1 and CDKN1A/p21(CIP1). CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing. Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the ′K+4′ motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the ′Lys-164′ monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis.

Specifications

Antigen DTL/CDT2
Applications Immunohistochemistry, Immunoprecipitation
Classification Polyclonal
Concentration 1 mg/ml
Conjugate Unconjugated
Formulation phosphate, tris citrate with 0.09% sodium azide; pH 7-8
Gene DTL
Gene Accession No. Q9NZJ0
Gene Alias CDT2, DCAF2, L2DTL, RAMP, DDB1 and CUL4 associated factor 2, DDB1- and CUL4-associated factor 2, RA regulated nuclear matrix associated protein, RA-regulated nuclear matrix-associated protein, denticleless protein homolog, lethal(2) denticleless protein homolog, retinoic acid-regulated
Gene Symbols DTL
Host Species Rabbit
Immunogen Between 375 and 425
Purification Method Antigen affinity chromatography
Quantity 10 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 51514
Target Species Human
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG
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