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Invitrogen™ DTL Polyclonal Antibody

Rabbit Polyclonal Antibody

$589.50

Specifications

Antigen DTL
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Applications Immunocytochemistry
Classification Polyclonal
Conjugate Unconjugated
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
PIPA5111035
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Invitrogen™
PA5111035
100 μL
Each for $589.50
Only null left
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PIPA5111036
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Invitrogen™
PA5111036
100 μL
Each for $589.50
Only null left
Add to Cart
 
Description

Description

Immunogen sequence: AGDLPLPSNT PTFSIKTSPA KARSPINRRG SVSSVSPKPP SSFKMSIRNW VTRTPSSSPP ITPPASETKI MSPRKALIPV SQKSSQA.

Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1 and CDKN1A/p21(CIP1). CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing. Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis.
Specifications

Specifications

DTL
Immunocytochemistry
Unconjugated
Rabbit
RUO
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Q9NZJ0
51514
Recombinant Protein corresonding to Human DTL. Recombinant protein control fragment (Product #RP-105875).
Antibody
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Polyclonal
Liquid
IgG
Human
DTL
2810047L02Rik; 5730564G15Rik; CDT2; CDW1; DCAF2; DDB1 and CUL4 associated factor 2; DDB1- and CUL4-associated factor 2; denticleless E3 ubiquitin protein ligase homolog; denticleless E3 ubiquitin protein ligase homolog (Drosophila); denticleless homolog; denticleless homolog (Drosophila); denticleless protein homolog; DTL; L2dtl; lethal(2) denticleless protein homolog; Meth A RAMP; Meth A retinoic acid-regulated nuclear matrix-associated protein; RA regulated nuclear matrix associated protein; RAMP; RA-regulated nuclear matrix-associated protein; Retinoic acid-regulated nuclear matrix-associated protein; RGD1310439
DTL
Primary
Antigen Affinity Chromatography
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