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Invitrogen™ DTX2 Polyclonal Antibody
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Catalog No. PIPA5109664
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100 μL
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PIPA5109664 100 μL
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Catalog No. PIPA5109664 Supplier Invitrogen™ Supplier No. PA5109664
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: MAMAPSPSLV QVYTSPAAVA VWEWQDGLGT WHPYSATVCS FIEQQFVQQK GQRFGLGSLA HSIPLGQADP SLAPYIIDLP SWTQFRQDTG TMRAVRRHLF PQHSAPGRGV VWEWLSDDGS WTAYEASVCD YLEQQVARGN QLVDLAPLGY NYTVNYTTHT QTNKTSSFCR SVRRQAGPPY PVTTIIAPPG HTGVACSCHQ CLSGSRTGPV SGRYRHSMTN LPAYPVPQHP PHRTASVFGT HQAFAPYNKP SLSGARSAPR LNTTNAWGAA PPSLGSQPLY.

DTX2 functions as an E3 ubiquitin ligase. Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.
TRUSTED_SUSTAINABILITY

Specifications

Antigen DTX2
Applications ELISA, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.49 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
Gene DTX2
Gene Accession No. Q86UW9, Q8R3P2
Gene Alias 2610524D08Rik; AA408415; AU022494; deltex 2 homolog; deltex 2 homolog (Drosophila); deltex 2, E3 ubiquitin ligase; deltex E3 ubiquitin ligase 2; deltex homolog 2; deltex2; Dtx2; hDTX2; KIAA1528; mDTX2; probable E3 ubiquitin-protein ligase DTX2; Protein deltex-2; ring finger protein 58; RING-type E3 ubiquitin transferase DTX2; RNF58; zinc ion binding protein
Gene Symbols DTX2
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human DTX2 (NP_065943.2).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 113878, 304591, 74198
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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