Invitrogen™ DTX3L Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA552708

Catalog No. PIPA552708

Description

Immunogen sequence: ERKPLSQQER DSCISPSEPE TKAEQKSNYF EVPLPYFEYF KYICPDKINS IEKRFGVNIE IQESSPNMVC LDFTSSRSGD LEAARESFAS EFQKNTEPLK QECVSLADSK QANKFKQELN HQFTKL Highest antigen sequence identity to the following orthologs: Mouse - 42%, Rat - 46%.

Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends. Without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomere elongation by recruiting telomerase to telomeres and increasing its processivity. May play a role in organogenesis.

Specifications

• Antigen: DTX3L
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: DTX3L
• Gene Alias: AU042200; Bbap; BC023741; B-lymphoma- and BAL-associated protein; deltex 3 like, E3 ubiquitin ligase; deltex 3-like; deltex 3-like (Drosophila); deltex E3 ubiquitin ligase 3L; DTX3L; E3 ubiquitin-protein ligase DTX3L; Protein deltex-3-like; RGD1565144; rhysin 2; Rhysin2; rhysin-2; RING-type E3 ubiquitin transferase DTX3L
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 151636
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Immunocytochemistry
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q8TDB6
• Gene Symbols: DTX3L
• Immunogen: Recombinant protein corresponding to Human DTX3L. Recombinant protein control fragment (Product #RP-89860).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov