Invitrogen™ DTYMK Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA560092

Catalog No. PIPA560092

Description

Immunogen sequence: RGALIVLEGV DRAGKSTQSR KLVEALCAAG HRAELLRFPE RSTEIGKLLS SYLQKKSDVE DHSVHLLFSA NRWEQVPLIK EKLSQGVTLV VDRYAFSGVA Highest antigen sequence identity to the following orthologs: Mouse - 87%, Rat - 87%.

Thymidylate kinase (DTYMK) catalyzes the phosphorylation of dTMP to form dTDP in the dTTP synthesis pathway for DNA synthesis. DTYMK is essential for DNA synthesis and is an important intermediate enzyme in the pathway of many pyrimidine analog drugs, including 5-Fluorouracil (5-FU), the chemotherapeutic drug of choice for several solid tumors. The human DTYMK gene was isolated via functional complementation of a Saccharomyces cerevisiae cell cycle mutant, cdc8. DTYMK mRNA levels and enzyme activities are regulated at the level of cell cycle and cell growth pathways.

Specifications

• Antigen: DTYMK
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: DTYMK
• Gene Alias: AU044245; CDC8; D10Ertd203e; deoxythymidylate kinase; deoxythymidylate kinase (thymidylate kinase); dTMP kinase; DTYMK; mtmk; PP3731; Thymidylate kinase; Tmk; TMPK; TYMK; TYPK
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 1841
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Immunocytochemistry
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: P23919
• Gene Symbols: DTYMK
• Immunogen: Recombinant protein corresponding to Human DTYMK. Recombinant protein control fragment (Product #RP-98924).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG