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DUOXA1 Rabbit anti-Human, Mouse, Polyclonal, Proteintech
SDP

Rabbit Polyclonal Antibody

Supplier:  Proteintech Group Inc 266321AP150UL

Encompass_Preferred

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Catalog No. 50-173-5405


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Description

Description

Dual oxidases DUOX1 and DUOX2 are NADPH oxidases which are involved in hydrogen peroxide production necessary for thyroid hormonogenesis. They form a heterodimer with specific maturation factors DUOXA1 and DUOXA2, respectively, which is essential for the maturation and function of the DUOX enzyme complexes. This gene encodes the DUOX1 activator or maturation factor DUOXA1. Rat studies identified a bidirectional promoter which controls the transcription of the DUOX1 and DUOXA1 genes. This protein is cotransported to the cell surface when coexpressed with DUOX1 and is retained in the endoplasmic reticulum when expressed without DUOX1 protein. The expression of this gene or the DUOX1 gene is not suppressed by thyroglobulin (Tg), a macromolecular precursor in thyroid hormone synthesis, while the expression of the DUOX2 and DUOXA2 are significantly suppressed by the Tg. This protein is also a p53-regulated neurogenic factor involved in p53 dependent neuronal differentiation. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Specifications

Specifications

DUOXA1
Polyclonal
Unconjugated
DUOXA1
Dual oxidase activator 1, DUOXA1, mol, NIP, Numb interacting protein, NUMBIP
Rabbit
Antigen Affinity Chromatography
RUO
213696, 90527
-20°C
Liquid
Western Blot
0.2 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Q1HG43, Q8VE49
DUOXA1
DUOXA1 Fusion Protein Ag24373
150 μL
Primary
Human, Mouse
Antibody
IgG
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