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DUOXA1 Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501981362
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50-198-1362 100 μL
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Catalog No. 50-198-1362 Supplier Bioss Supplier No. BS11433R
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Description

Rabbit Polyclonal Antibody

Dual oxidases DUOX1 and DUOX2 are NADPH oxidases which are involved in hydrogen peroxide production necessary for thyroid hormonogenesis. They form a heterodimer with specific maturation factors DUOXA1 and DUOXA2, respectively, which is essential for the maturation and function of the DUOX enzyme complexes. This gene encodes the DUOX1 activator or maturation factor DUOXA1. Rat studies identified a bidirectional promoter which controls the transcription of the DUOX1 and DUOXA1 genes. This protein is cotransported to the cell surface when coexpressed with DUOX1 and is retained in the endoplasmic reticulum when expressed without DUOX1 protein. The expression of this gene or the DUOX1 gene is not suppressed by thyroglobulin (Tg), a macromolecular precursor in thyroid hormone synthesis, while the expression of the DUOX2 and DUOXA2 are significantly suppressed by the Tg. This protein is also a p53-regulated neurogenic factor involved in p53 dependent neuronal differentiation. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Specifications

Antigen DUOXA1
Applications Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene DUOXA1
Gene Accession No. Q1HG43
Gene Alias BC019755; BOS_10907; Dual oxidase activator 1; Dual oxidase maturation factor 1; dual oxidase maturation factor 1 alpha; dual oxidase maturation factor 1 beta; dual oxidase maturation factor 1 delta; dual oxidase maturation factor 1 gamma; DUOXA1; homolog of Drosophila Numb-interacting protein; mol; NIP; Nip1; Numb-interacting protein; NUMBIP
Gene Symbols DUOXA1
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide derived from human DUOXA1.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 90527
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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