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Invitrogen™ PD-L1 (CD274) (Durvalumab Biosimilar) Recombinant Human Monoclonal Antibody
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Catalog No. PIMA542048
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100 μg
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PIMA542048 100 μg
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Catalog No. PIMA542048 Supplier Invitrogen™ Supplier No. MA542048
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Description

Human Recombinant Monoclonal Antibody

Endotoxin level <0.01EU/μg by LAL method Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 °C for one week. Store at -20 to -80 °C for twelve months from the date of receipt. This product is a Humanized mouse antibody.

Programmed death receptor ligand 1 (PD-L1, also called B7-H1) is a recently described B7 family member. To date, one specific receptor has been identified that can be ligated by PD-L1. This receptor, programmed death receptor 1 (PD-1), has been shown to negatively regulate T-cell receptor (TCR) signaling. Upon ligating its receptor, PD-L1 has been reported to decrease TCR-mediated proliferation and cytokine production. PD-L1 expression was found to be abundant on many murine and human cancers and could be further up-regulated upon IFN-gamma stimulation. Thus, PD-L1 might play an important role in tumor immune evasion.
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Specifications

Antigen PD-L1 (CD274) (Durvalumab Biosimilar)
Applications ELISA, Flow Cytometry
Classification Recombinant Monoclonal
Concentration 0.63 mg/mL
Conjugate Unconjugated
Formulation PBS with no preservative; pH 7.4
Gene Cd274
Gene Accession No. Q9NZQ7
Gene Alias A530045L16Rik; B7 homolog 1; B7-H; B7h1; B7-H1; Cd274; CD274 antigen; CD274 molecule; PDCD1 ligand 1; Pdcd1l1; Pdcd1lg1; Pdl1; PD-L1; pdl-1; Programmed cell death 1 ligand 1; programmed death ligand 1; RGD1566211; sCD274; soluble CD274; soluble PD L1; sPD L1
Gene Symbols Cd274
Host Species Human
Immunogen Human CD274/B7-H1/PDL1.
Purification Method Protein A/G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 29126
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG1 κ
Target Molecule Chemical
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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