DUSP10 Mouse anti-Human, Clone: OTI3D8, lyophilized, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene CF806754

Catalog No. 50-166-7959

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAPK superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product binds to and inactivates p38 and SAPK/JNK, but not MAPK/ERK. Its subcellular localization is unique; it is evenly distributed in both the cytoplasm and the nucleus. This gene is widely expressed in various tissues and organs, and its expression is elevated by stress stimuli. Three transcript variants encoding two different isoforms have been found for this gene.

Specifications

• Antigen: DUSP10
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: DUSP10
• Gene Alias: MKP-5, MKP5
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 11221
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Western Blot
• Clone: OTI3D8
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene Accession No.: Q9Y6W6
• Gene Symbols: DUSP10
• Immunogen: Human recombit protein fragment corresponding to amino acids 180-482 of human DUSP10 produced in E.coli.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2a