Invitrogen™ DUSP12 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA589113

Catalog No. PIPA589113

Description

Immunogen sequence: LMKTDQLPFE KAYEKLQILK PEAKMNEGFE WQLKLYQAMG YEVDTSSAIY KQYRLQKVTE KYPELQNLPQ ELFAVDPTTV SQGLKDEVLY KCRKCRRSLF RSSSILDHRE GSGPIAFAHK RMTPSSMLTT GRQAQCTSYF I; Positive Samples: Jurkat, A-549; Cellular Location: Nucleus.

Dual specificity phosphatase (DUSP) inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. DUSPs can be divided into six subgroups on the basis of sequence similarity (PRLs, Cdc14 phosphatases, PTENs, myotubularins, MKPs, atypical DUSPs). DUSP inhibitors might be used to manipulate MAPK and cellular responses in both positive and negative ways. The regulated expression and activity of DUSP family members in different cells and tissues controls MAPK intensity and duration to determine the type of physiological response. DUSP12 (YVH1, GKAP) contains the consensus DUSP catalytic domain as well as an extended C-terminal domain of unknown function, thought to be related to its potential role in glucokinase regulation. It is localized in the cytoplasm and nucleus.

Specifications

• Antigen: DUSP12
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Dusp12
• Gene Alias: 1190004O14Rik; AA027408; AW049275; dual specificity phosphatase 12; dual specificity phosphatase T-DSP4; Dual specificity phosphatase VH1; dual specificity protein phosphatase 12; Dual specificity tyrosine phosphatase YVH1; DUSP1; Dusp12; ESTM36; LMW-DSP4; mVH1; serine/threonine specific protein phosphatase; T-DSP4; VH1; YVH1; YVH1 protein-tyrosine phosphatase ortholog
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 11266, 80915
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 2.54 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: Q9D0T2, Q9UNI6
• Gene Symbols: Dusp12
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 130-270 of human DUSP12 (NP_0091711).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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