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Invitrogen™ DUSP14 Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA528094
Description
Recommended positive controls: MKP-6 tansfected 293T cell. Predicted reactivity: Mouse (100%), Rat (100%), Rhesus Monkey (100%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
In addition to antigen recognition by the T-cell receptor, T-cell activation requires a second signal from a costimulatory receptor, such as CD28 (MIM 186760), which interacts with B7-1 (CD80; MIM 112203) and B7-2 (CD86; MIM 601020) ligands on antigen-presenting cells. CD28 costimulation induces transcription of interleukin-2 (IL2; MIM 147680) and stabilizes newly synthesized IL2 through the activation of mitogen-activated protein kinases (MAPKs), such as ERK (e.g., MAP2K4; MIM 601335) and JNK (see MIM 601158), and the subsequent creation of AP1 transcription factor (see MIM 165160). DUSP14 is a negative regulator of CD28 signaling.
Specifications
DUSP14 | |
Polyclonal | |
Unconjugated | |
DUSP14 | |
1110014C10Rik; 2310042C07Rik; D11Ertd395e; dual specificity phosphatase 14; dual specificity protein phosphatase 14; DUSP14; MAP kinase phosphatase 6; MAP kinase phsophatase 6; mitogen-activated protein kinase phosphatase 6; Mkp-1 like protein tyrosine phosphatase; MKP-1-like protein tyrosine phosphatase; MKP6; MKP-6; MKP-L | |
Rabbit | |
Protein A | |
RUO | |
11072 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Western Blot | |
2 mg/mL | |
PBS with 40% glycerol and 0.01% thimerosal; pH 7 | |
O95147 | |
DUSP14 | |
Synthetic peptide corresponding to a region within amino acids 136 and 198 of Human MKP-6. | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG |
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