Invitrogen™ DUSP14 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA528094

Catalog No. PIPA528094

Description

Recommended positive controls: MKP-6 tansfected 293T cell. Predicted reactivity: Mouse (100%), Rat (100%), Rhesus Monkey (100%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

In addition to antigen recognition by the T-cell receptor, T-cell activation requires a second signal from a costimulatory receptor, such as CD28 (MIM 186760), which interacts with B7-1 (CD80; MIM 112203) and B7-2 (CD86; MIM 601020) ligands on antigen-presenting cells. CD28 costimulation induces transcription of interleukin-2 (IL2; MIM 147680) and stabilizes newly synthesized IL2 through the activation of mitogen-activated protein kinases (MAPKs), such as ERK (e.g., MAP2K4; MIM 601335) and JNK (see MIM 601158), and the subsequent creation of AP1 transcription factor (see MIM 165160). DUSP14 is a negative regulator of CD28 signaling.

Specifications

• Antigen: DUSP14
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: DUSP14
• Gene Alias: 1110014C10Rik; 2310042C07Rik; D11Ertd395e; dual specificity phosphatase 14; dual specificity protein phosphatase 14; DUSP14; MAP kinase phosphatase 6; MAP kinase phsophatase 6; mitogen-activated protein kinase phosphatase 6; Mkp-1 like protein tyrosine phosphatase; MKP-1-like protein tyrosine phosphatase; MKP6; MKP-6; MKP-L
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 11072
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 2 mg/mL
• Formulation: PBS with 40% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: O95147
• Gene Symbols: DUSP14
• Immunogen: Synthetic peptide corresponding to a region within amino acids 136 and 198 of Human MKP-6.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG