Invitrogen™ DUSP22 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5118836

Catalog No. PIPA5118836

Description

Antibody detects endogenous levels of total DUSP22.

Mitogen-activated protein (MAP) kinases are a large class of proteins involved in signal transduction pathways that are activated by a range of stimuli and mediate a number of physiological and pathological changes in the cell. Dual specificity phosphatases (DSPs) are a subclass of the protein tyrosine phosphatase (PTP) gene superfamily, which are selective for dephosphorylating critical phosphothreonine and phosphotyrosine residues within MAP kinases. DSP gene expression is induced by a host of growth factors and/or cellular stresses, thereby negatively regulating MAP kinase superfamily members including MAPK/ERK, SAPK/JNK and p38. DUSP22 dephosphorylates ERK2 MAP kinase and JNK. DUSP22 displays highest in thymus, but it is also detectable in monocytes and lymphocytes.

Specifications

• Antigen: DUSP22
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Dusp22
• Gene Alias: DKFZp586F2224; dual specificity phosphatase 22; dual specificity protein phosphatase 22; Dusp22; homolog of mouse dual specificity phosphatase LMW-DSP2; JKAP; JNK-stimulating phosphatase 1; JNK-stimulatory phosphatase-1; JSP 1; JSP1; JSP-1; LMWDSP2; LMW-DSP2; low molecular weight dual specificity phosphatase 2; MAP kinase phosphatase x; mi; mitogen-activated protein kinase phosphatase x; MKPX; MKP-x; PYST2; VHX
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 105352, 56940
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q99N11, Q9NRW4
• Gene Symbols: Dusp22
• Immunogen: A synthesized peptide derived from human DUSP22(Accession Q9NRW4), corresponding to amino acid residues D113-E163.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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