Invitrogen™ DUSP3 Monoclonal Antibody (2#), Invitrogen™

Catalog No.	Quantity
PIMA543847	100 μL
PIMA543848	20 μL

Catalog No. PIMA543847 Supplier Invitrogen™ Supplier No. MA543847

Description

Mouse Monoclonal Antibody

Protein tyrosine phosphatases (PTPs) are a group of enzymes that remove phosphate groups from phosphorylated tyrosine residues on proteins. Together with tyrosine kinases, PTPs regulate the phosphorylation state of many important signaling molecules, such as the MAP kinase family. Recently, increasing attention has been focused on the growing family of PTPs. Like PTKs, PTPs have been implicated in cell signaling, cell growth and proliferation, and oncogenic transformation. Moreover, some PTPs can be involved in cell cycle regulation and embryogenesis. Dual specificity phosphatases (DSPs) are an emerging subclass of the protein tyrosine phosphatase (PTP) gene superfamily, which appears to be selective for dephosphorylating the critical phosphothreonine and phosphotyrosine residues. The prototypical DSP is the VH1 gene in vaccinia virus expressed in late-stage viral infection. A shallow active site pocket in VHR allows for the hydrolysis of phosphorylated serine, threonine, or tyrosine protein residues, whereas the deeper active site of protein tyrosine phosphatases (PTPs) restricts substrate specificity to only phosphotyrosine.

Specifications

• Antigen: DUSP3
• Applications: Western Blot
• Classification: Monoclonal
• Clone: 2#
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.05% ProClin 300; pH 7.4
• Gene: Dusp3
• Gene Accession No.: P51452
• Gene Alias: 2210015O03Rik; 5031436O03Rik; dual specificity phosphatase 3; dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related); dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related)-like; dual specificity protein phosphatase 3; Dual specificity protein phosphatase VHR; DUSP 3; DUSP3; DUSP-3; RGD1560049; serine/threonine specific protein phosphatase; T-DSP11; Vaccinia H1-related phosphatase; vaccinia virus phosphatase VH1-related; VHR
• Gene Symbols: Dusp3
• Host Species: Mouse
• Immunogen: Ser2-Pro185 (Accession P51452), with N-terminal His Tag.
• Purification Method: Protein A/G
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 1845
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG2a κ