Invitrogen™ DUSP3 Polyclonal Antibody

Catalog No.	Quantity
PIPA579174	100 μg

Catalog No. PIPA579174 Supplier Invitrogen™ Supplier No. PA579174

Description

Rabbit Polyclonal Antibody

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 μg/mL. Positive Control - WB: human MCF-7 whole cell, human MDA-MB-453 whole cell, human Caco-2 whole cell, human HepG2 whole cell, rat skeletal muscle tissue, rat heart tissue, mouse skeletal muscle tissue, mouse heart tissue.

Protein tyrosine phosphatases (PTPs) are a group of enzymes that remove phosphate groups from phosphorylated tyrosine residues on proteins. Together with tyrosine kinases, PTPs regulate the phosphorylation state of many important signaling molecules, such as the MAP kinase family. Recently, increasing attention has been focused on the growing family of PTPs. Like PTKs, PTPs have been implicated in cell signaling, cell growth and proliferation, and oncogenic transformation. Moreover, some PTPs can be involved in cell cycle regulation and embryogenesis. Dual specificity phosphatases (DSPs) are an emerging subclass of the protein tyrosine phosphatase (PTP) gene superfamily, which appears to be selective for dephosphorylating the critical phosphothreonine and phosphotyrosine residues. The prototypical DSP is the VH1 gene in vaccinia virus expressed in late-stage viral infection. A shallow active site pocket in VHR allows for the hydrolysis of phosphorylated serine, threonine, or tyrosine protein residues, whereas the deeper active site of protein tyrosine phosphatases (PTPs) restricts substrate specificity to only phosphotyrosine.

Specifications

• Antigen: DUSP3
• Applications: Western Blot
• Classification: Polyclonal
• Concentration: 500 μg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 4mg trehalose and 0.01mg sodium azide
• Gene: Dusp3
• Gene Accession No.: P51452, Q9D7X3
• Gene Alias: 2210015O03Rik; 5031436O03Rik; dual specificity phosphatase 3; dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related); dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related)-like; dual specificity protein phosphatase 3; Dual specificity protein phosphatase VHR; DUSP 3; DUSP3; DUSP-3; RGD1560049; serine/threonine specific protein phosphatase; T-DSP11; Vaccinia H1-related phosphatase; vaccinia virus phosphatase VH1-related; VHR
• Gene Symbols: Dusp3
• Host Species: Rabbit
• Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human DUSP3 (155-171aa RQNREIGPNDGFLAQLC).
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 1845, 498003, 72349
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Lyophilized
• Isotype: IgG