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Invitrogen™ DUSP8 Polyclonal Antibody
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Catalog No. PIPA582712
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100 μL
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PIPA582712 100 μL
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Catalog No. PIPA582712 Supplier Invitrogen™ Supplier No. PA582712
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: SDDAYRFVKD RRPSISPNFN FLGQLLEYER SLKLLAALQG DPGTPSGTPE PPPSPAAGAP LPRLPPPTSE SAATGNAAAR Highest antigen sequence indentity to the following orthologs: Mouse - 84%, Rat - 84%.

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates SAPK/JNK and p38, is expressed predominantly in the adult brain, heart, and skeletal muscle, is localized in the cytoplasm, and is induced by nerve growth factor and insulin. An intronless pseudogene for DUSP8 is present on chromosome 10q11.2.
TRUSTED_SUSTAINABILITY

Specifications

Antigen DUSP8
Applications Immunohistochemistry (Paraffin), Immunocytochemistry
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene DUSP8
Gene Accession No. Q13202
Gene Alias 5530400B01Rik; AI593498; C11orf81; dual specificity phosphatase 8; dual specificity protein phosphatase 8; Dual specificity protein phosphatase hVH-5; Dusp8; FLJ42476; FLJ42958; H1 phosphatase, vaccinia virus homolog; Hb5; HVH-5; HVH8; M3/6; neuronal tyrosine threonine phosphatase 1; neuronal tyrosine/threonine phosphatase 1; Nttp1; OTTHUMP00000164487; serine/threonine specific protein phosphatase; VH5
Gene Symbols DUSP8
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human DUSP8. Recombinant protein control fragment (Product #RP-91582).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1850
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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