Invitrogen™ DUSP8 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5109668

Catalog No. PIPA5109668

Description

Immunogen sequence: NleAGDRLPR KVNl.

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates SAPK/JNK and p38, is expressed predominantly in the adult brain, heart, and skeletal muscle, is localized in the cytoplasm, and is induced by nerve growth factor and insulin. An intronless pseudogene for DUSP8 is present on chromosome 10q11.2.

Specifications

• Antigen: DUSP8
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: DUSP8
• Gene Alias: 5530400B01Rik; AI593498; C11orf81; dual specificity phosphatase 8; dual specificity protein phosphatase 8; Dual specificity protein phosphatase hVH-5; Dusp8; FLJ42476; FLJ42958; H1 phosphatase, vaccinia virus homolog; Hb5; HVH-5; HVH8; M3/6; neuronal tyrosine threonine phosphatase 1; neuronal tyrosine/threonine phosphatase 1; Nttp1; OTTHUMP00000164487; serine/threonine specific protein phosphatase; VH5
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 18218, 1850, 361679
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot, Immunocytochemistry
• Concentration: 0.97 mg/mL
• Formulation: PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
• Gene Accession No.: O09112, Q13202
• Gene Symbols: DUSP8
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human DUSP8 (NP_0044112).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG