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Invitrogen™ DUT Polyclonal Antibody
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Catalog No. PIPA530955
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100 μL
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PIPA530955 100 μL
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Catalog No. PIPA530955 Supplier Invitrogen™ Supplier No. PA530955
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: 293T, A431, Jurkat, Raji. Predicted reactivity: Mouse (87%), Rat (86%), Chicken (82%), Bovine (89%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19.
TRUSTED_SUSTAINABILITY

Specifications

Antigen DUT
Applications Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Classification Polyclonal
Concentration 0.49 mg/mL
Conjugate Unconjugated
Formulation 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
Gene Dut
Gene Accession No. P33316
Gene Alias 5031412I06Rik; 5133400F09Rik; D2Bwg0749e; Deoxyuridine 5'-triphosphate nucleotidohydrolase; deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial; deoxyuridine triphosphatase; Dut; Dutp; dUTP diphosphatase; dUTP nucleotidohydrolase; dUTP pyrophosphatase; dUTPase; FLJ20622; PIP4; PPAR-interacting protein 4
Gene Symbols Dut
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of human DUT. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1854
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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