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dUTPase Rabbit anti-Human, Polyclonal, Bioss
SDP

Rabbit Polyclonal Antibody

Supplier:  Bioss BS1721R

Encompass_Preferred

Catalog No. 50-198-4075


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Description

Description

This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19.
Specifications

Specifications

dUTPase
Polyclonal
Unconjugated
Dut
5031412I06Rik; 5133400F09Rik; D2Bwg0749e; Deoxyuridine 5′-triphosphate nucleotidohydrolase; Deoxyuridine 5′-triphosphate nucleotidohydrolase, mitochondrial; deoxyuridine triphosphatase; DUT; Dutp; dUTP diphosphatase; dUTP nucleotidohydrolase; dUTP pyrophosphatase; dUTPase; FLJ20622; PIP4; PPAR-interacting protein 4
Rabbit
Protein A
RUO
1854
-20°C
Liquid
Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
1 μg/mL
PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
P33316
Dut
KLH conjugated synthetic peptide derived from human dUTPase .
100 μL
Primary
Human
Antibody
IgG
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