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Invitrogen™ DUX4 Monoclonal Antibody (P2B1), APC
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Catalog No. PIMA545265
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100 μg
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PIMA545265 100 μg
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Catalog No. PIMA545265 Supplier Invitrogen™ Supplier No. MA545265
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Description

Mouse Monoclonal Antibody

1 μg/mL of MA5-45265 was sufficient for detection of DUX4 in 20 μg of HeLa cell lysate by ECL immunoblot analysis using goat anti-mouse IgG: HRP as teh secondary. Detects approximately 45kDa. No cross-reactivity with DUX4c.

DUX4 (also known as Double homeobox 4) is the leading candidate causative gene for facioscapulohumeral dystrophy (FSHD), a degenerative skeletal muscle disease and one of the most common muscular dystrophies. FSHD is caused by the deletion of a subset of D4Z4 macrosatellite repeats on chromosome 4. Each repeat contains a retrogene encoding the double-homeobox factor DUX4. DUX4 expression is epigenetically suppressed in differentiated tissues and the residual DUX4 transcripts are spliced to remove the carboxyterminal domain that has been associated with cell toxicity. In FSHD individuals, the expression of the full-length DUX4 transcript is not completely suppressed in skeletal muscle, and possibly other differentiated tissues, and results in a small percentage of cells expressing relatively abundant amounts of the full-length DUX4 mRNA and protein.
TRUSTED_SUSTAINABILITY

Specifications

Antigen DUX4
Applications Immunohistochemistry, Western Blot, Immunocytochemistry
Classification Monoclonal
Clone P2B1
Concentration 1 mg/mL
Conjugate APC
Formulation 2.48mM MES, 95.64mM phosphate with 0.5M EDTA and no preservative; pH 7.4
Gene Dux4
Gene Accession No. Q9UBX2
Gene Alias AW822073; double homeobox; double homeobox 4; double homeobox 4-like; double homeobox B-like 1; double homeobox protein 10; Double homeobox protein 4; double homeobox protein 4/10; Dux; DUX10; Dux4; DUX4L; Duxbl; Duxbl1; EG664783; homeobox protein; RGD1311053
Gene Symbols Dux4
Host Species Mouse
Immunogen C-terminal 76 amino acids of DUX4 with glutathione-s-transferase (gst) tag.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 100288687
Target Species Human, Mouse
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG1
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WARNING: Cancer - www.P65Warnings.ca.gov
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