DUX4 Rabbit anti-Human, Polyclonal, Bioss

Catalog No.	Quantity
50-198-2181	100 μL

Catalog No. 50-198-2181 Supplier Bioss Supplier No. BS12369R

Description

Rabbit Polyclonal Antibody

DUX4 (also known as Double homeobox 4) is the leading candidate causative gene for facioscapulohumeral dystrophy (FSHD), a degenerative skeletal muscle disease and one of the most common muscular dystrophies. FSHD is caused by the deletion of a subset of D4Z4 macrosatellite repeats on chromosome 4. Each repeat contains a retrogene encoding the double-homeobox factor DUX4. DUX4 expression is epigenetically suppressed in differentiated tissues and the residual DUX4 transcripts are spliced to remove the carboxyterminal domain that has been associated with cell toxicity. In FSHD individuals, the expression of the full-length DUX4 transcript is not completely suppressed in skeletal muscle, and possibly other differentiated tissues, and results in a small percentage of cells expressing relatively abundant amounts of the full-length DUX4 mRNA and protein.

Specifications

• Antigen: DUX4
• Applications: Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 1 μg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
• Gene: Dux4
• Gene Accession No.: Q9UBX2
• Gene Alias: Double homeobox 10; double homeobox 4; double homeobox 4-like; Double homeobox protein 10; Double homeobox protein 4; double homeobox protein 4/10; DUX10; DUX4; DUX4 (HGNC:50800); DUX4L; DUX4L1
• Gene Symbols: Dux4
• Host Species: Rabbit
• Immunogen: KLH conjugated synthetic peptide derived from human DUX4.
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 100288687
• Target Species: Human
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG