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Invitrogen™ Dynactin 1 Monoclonal Antibody (6B11)
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Catalog No. PIMA518308
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PIMA518308 100 μL
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Catalog No. PIMA518308 Supplier Invitrogen™ Supplier No. MA518308
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Description

Mouse Monoclonal Antibody

This antibody detects endogenous levels of DCTN1 at a molecular weight of 150 kDa and does not cross-react with related proteins. Purity is >95% by SDS-PAGE.

This gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. Dynactin is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein (CAP-Gly) domain in its N-terminus. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause distal hereditary motor neuronopathy type VIIB (HMN7B) which is also known as distal spinal and bulbar muscular atrophy (dSBMA).
TRUSTED_SUSTAINABILITY

Specifications

Antigen Dynactin 1
Applications Immunoprecipitation, Western Blot
Classification Monoclonal
Clone 6B11
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
Gene DCTN1
Gene Accession No. Q14203
Gene Alias 150 kDa dynein-associated polypeptide; AL022633; DAP 150; DAP150; DAP-150; DCTN 1; DCTN1; DP 150; DP150; DP-150; dynactin 1; dynactin 1 (p150, glued homolog, Drosophila); dynactin 1, retrograde axonal transport; dynactin subunit 1; Dynactin1; Glued; HMN7B; OTTHUMP00000202491; p135; p150; p150 glued; p150 glued homolog; p150>glued>; p150glued; p150-glued
Gene Symbols DCTN1
Host Species Mouse
Immunogen Synthetic peptide corresponding to the N-terminal of human Dynactin 1.
Purification Method Antigen Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1639
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG2b
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