Invitrogen™ Dynactin 1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5106892

Catalog No. PIPA5106892

Description

Antibody detects endogenous levels of total DCTN1.

This gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. Dynactin is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein (CAP-Gly) domain in its N-terminus. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause distal hereditary motor neuronopathy type VIIB (HMN7B) which is also known as distal spinal and bulbar muscular atrophy (dSBMA).

Specifications

• Antigen: Dynactin 1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: DCTN1
• Gene Alias: 150 kDa dynein-associated polypeptide; AL022633; DAP 150; DAP150; DAP-150; DCTN 1; DCTN1; DP 150; DP150; DP-150; dynactin 1; dynactin 1 (p150, glued homolog, Drosophila); dynactin 1, retrograde axonal transport; dynactin subunit 1; Dynactin1; Glued; HMN7B; OTTHUMP00000202491; p135; p150; p150 glued; p150 glued homolog; p150>glued>; p150glued; p150-glued
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 13191, 1639, 29167
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: O08788, P28023, Q14203
• Gene Symbols: DCTN1
• Immunogen: A synthesized peptide derived from human DCTN1(Accession Q14203), corresponding to amino acid residues G1246-S1278.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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