Invitrogen™ Dynactin 3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA560864

Catalog No. PIPA560864

Description

Immunogen sequence: FILSQVALLE QVNALVPMLD SAHIKAVPEH AARLQRLAQI HIQQQDQCVE ITEESKALLE EYNKTTMLLS KQFVQWDELL CQLEAATQVK PA Highest antigen sequence identity to the following orthologs: Mouse - 95%, Rat - 97%.

This gene encodes the smallest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, cytokinesis, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like most other dynactin subunits, exists only as a part of the dynactin complex. It is primarily an alpha-helical protein with very little coiled coil, and binds directly to the largest subunit (p150) of dynactin. Alternative splicing of this gene generates 2 transcript variants.

Specifications

• Antigen: Dynactin 3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: DCTN3
• Gene Alias: DCTN22; DCTN-22; DCTN3; dynactin 3; dynactin 3 (p22); dynactin complex subunit 22 kDa subunit; dynactin light chain; dynactin light chain (P24); dynactin light chain p24; Dynactin subunit 3; MGC111190; p22; p24; p24 dynactin light chain
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 11258
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Immunocytochemistry
• Concentration: 0.2 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: O75935
• Gene Symbols: DCTN3
• Immunogen: Recombinant protein corresponding to Human Dynactin 3. Recombinant protein control fragment (Product #RP-92986).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG