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Invitrogen™ Dynamin 1 Monoclonal Antibody (3G4B6)
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Catalog No. PIMA515285
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100 μL
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PIMA515285 100 μL
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Catalog No. PIMA515285 Supplier Invitrogen™ Supplier No. MA515285
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Description

Mouse Monoclonal Antibody

MA5-15285 targets Dynamin-1 in indirect ELISA, IHC and WB applications and shows reactivity with Human samples. The MA5-15285 immunogen is purified recombinant fragment of human Dynamin-1 expressed in E. Coli. MA5-15285 detects Dynamin-1 which has a predicted molecular weight of approximately 97kDa.

Dynamin is a GTPase required for endocytosis of clathrin coated vesicles from the membrane. Dynamin's involvement in endocytosis was first discovered during the characterization of the temperature sensitive parylytic shibire mutation from Drosophila melanogaster. Three closely related isoforms have been identified in mammals. Dynamin1 is expressed exclusively in neurons, dynamin2 is ubiquitously expressed and dynamin3 is expressed primarily in the testes. Each of these isoforms of dynamin also has several splice variants. This suggests that each isoform/splice variant may have separate intracellular targets or function in the budding of distinct vesicle types. Common domain features of the dynamin proteins include an amino acid terminal GTPase domain, a central pleckstrin homology domain and a highly basic proline rich carboxyl terminus with several Src homology 3 (SH3) domains. These SH3 domains target the dynamin to the clathrin coated pit. Dynamin is known to interact with at least two proteins, AP2 adaptor protein complex and amphiphysin.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Dynamin 1
Applications ELISA, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
Classification Monoclonal
Clone 3G4B6
Concentration Conc. Not Determined
Conjugate Unconjugated
Formulation Ascites with 0.03% sodium azide
Gene DNM1
Gene Accession No. P21575, P39053, Q05193
Gene Alias AI838169; B-dynamin; D100; Dnm; Dnm1; Dyn1; dynamin 1; Dynamin BREDNM19; dynamin i; dynamin, brain; Dynamin1; Dynamin-1; EC 3.6.5.5; EIEE31; Ftfl; Kiaa4093; mKIAA4093; Neuronal dynamin; OTTHUMP00000215500
Gene Symbols DNM1
Host Species Mouse
Immunogen Purified recombinant fragment of human Dynamin-1 expressed in E. Coli.
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 13429, 140694, 1759
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG2a
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