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Invitrogen™ Dynamin 1 Monoclonal Antibody (A1A12)
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Catalog No. PIMA534957
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100 μL
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PIMA534957 100 μL
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Catalog No. PIMA534957 Supplier Invitrogen™ Supplier No. MA534957
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Description

Mouse Monoclonal Antibody

Positive Control: PC-3M cell lysates, MG-63, SiHa, A549.

Dynamin is a GTPase required for endocytosis of clathrin coated vesicles from the membrane. Dynamin's involvement in endocytosis was first discovered during the characterization of the temperature sensitive parylytic shibire mutation from Drosophila melanogaster. Three closely related isoforms have been identified in mammals. Dynamin1 is expressed exclusively in neurons, dynamin2 is ubiquitously expressed and dynamin3 is expressed primarily in the testes. Each of these isoforms of dynamin also has several splice variants. This suggests that each isoform/splice variant may have separate intracellular targets or function in the budding of distinct vesicle types. Common domain features of the dynamin proteins include an amino acid terminal GTPase domain, a central pleckstrin homology domain and a highly basic proline rich carboxyl terminus with several Src homology 3 (SH3) domains. These SH3 domains target the dynamin to the clathrin coated pit. Dynamin is known to interact with at least two proteins, AP2 adaptor protein complex and amphiphysin.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Dynamin 1
Applications Flow Cytometry, Western Blot, Immunocytochemistry
Classification Monoclonal
Clone A1A12
Concentration 2 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol, 0.2% BSA and 0.05% sodium azide; pH 7.4
Gene DNM1
Gene Accession No. Q05193
Gene Alias AI838169; B-dynamin; D100; Dnm; Dnm1; Dyn1; dynamin 1; Dynamin BREDNM19; dynamin i; dynamin, brain; Dynamin1; Dynamin-1; EC 3.6.5.5; EIEE31; Ftfl; Kiaa4093; mKIAA4093; Neuronal dynamin; OTTHUMP00000215500
Gene Symbols DNM1
Host Species Mouse
Immunogen Recombinant protein within Human Dynamin 1 aa 555-770.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1759
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles, store in dark
Product Type Antibody
Form Liquid
Isotype IgG2a
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