Invitrogen™ Dynamin 3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA1662

Catalog No. PA1662

Description

PA1-662 detects dynamin III (Dyn3) from rat, mouse, and human tissues and cells. PA1-662 has been successfully used in Western blot procedures. By Western blot, this antibody detects an ~100 kDa protein representing Dyn3 from HeLa cell lysate. PA1-662 immunizing peptide corresponds to amino acid residues 623-639 from rat Dyn3. PA1-662 immunizing peptide (Cat. # PEP-057) is available for use in neutralization and control experiments.

The dynamins are a family of 100 kDa GTPases transcribed from at least three separate genes. At least four mRNA splice variants for each dynamin have been described. Dynamins contain several conserved regions including the conserved, amino-terminal GTPase domain, a centrally located membrane-binding plekstrin homology domain (PHD), and a coiled-coil region located in front of a proline-rich domain (PRD). The PRD is thought to mediate interactions between dynamin and numerous other cellular proteins. Dynamin I is expressed exclusively in neurons, dynamin II is ubiquitously expressed, and dynamin III is thought to be restricted to expression in the brain, testis, heart, and lung. The dynamins participate in the cellular process of clathrin-mediated and fluid-phase endocytosis.

Specifications

• Antigen: Dynamin 3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Dnm3
• Gene Alias: 9630020E24Rik; AW061159; B230343F03Rik; C530045C17; DNM3; Dyn3; Dyna III; dynamin 3; dynamin family member; Dynamin III; dynamin, testicular; dynamin-2; Dynamin-3; KIAA0820; mKIAA0820; T-dynamin; testicular dynamin
• Host Species: Rabbit
• Purification Method: Ammonium sulfate precipitation
• Regulatory Status: RUO
• Gene ID (Entrez): 103967, 171574, 26052
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: Conc. Not Determined
• Formulation: PBS with 1 mg/mL BSA and 0.05% sodium azide
• Gene Accession No.: Q08877, Q8BZ98, Q9UQ16
• Gene Symbols: Dnm3
• Immunogen: Synthetic Peptide: C P(623) D K S F T E N D E N G Q A E N F(639).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG