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Invitrogen™ DYNC1I2 Polyclonal Antibody
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Catalog No. PIPA522229
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PIPA522229 100 μL
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Catalog No. PIPA522229 Supplier Invitrogen™ Supplier No. PA522229
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: HeLa. Predicted reactivity: Mouse (97%), Rat (97%), Xenopus laevis (93%), Pig (98%), Chicken (94%), Rhesus Monkey (100%), Bovine (98%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Dyneins are multi-subunit, high molecular weight ATPases that interact with microtubules to generate force by converting the chemical energy of ATP into the mechanical energy of movement. Cytoplasmic or axonemal Dynein heavy, intermediate, light and light-intermediate chains are all components of minus end-directed motors; the complex that transports cellular cargos towards the central region of the cell. Axonemal Dynein motors contain one to three non-identical heavy chains and cause a sliding of microtubules in the axonemes of cilia and flagella in a mechanism necessary for cilia to beat and propel the cell. Cytoplasmic Dynein is an approximately 12 subunit complex of two heavy chains, two intermediate chains to anchor Dynein to its cargo, four smaller intermediate chains and several light chains. It performs functions necessary for cell survival such as organelle transport and centrosome assembly. The carboxy-terminus of Dynein is important for microtubule-dependent motility and is highly conserved, while the amino-terminal regions are more variable. Several proteins regulate Dynein activity, including Dynactin, LIS1 and nudel (nudE-like).
TRUSTED_SUSTAINABILITY

Specifications

Antigen DYNC1I2
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.3 mg/mL
Conjugate Unconjugated
Formulation 0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
Gene DYNC1I2
Gene Accession No. O88487, Q13409
Gene Alias 3110079H08Rik; AW554389; Cytoplasmic dynein 1 intermediate chain 2; cytoplasmic dynein intermediate chain 2; cytoplasmic dynein intermediate chain 2 isoform 2.1; cytoplasmic dynein intermediate chain 2 isoform 2.2; cytoplasmic dynein intermediate chain 2 isoform 2.5; DH IC-2; DIC74; DNCI2; DNCIC2; Dync1i2; dynein cytoplasmic 1 intermediate chain 2; dynein intermediate chain 2, cytosolic; dynein, cytoplasmic 1, intermediate chain 2; dynein, cytoplasmic, intermediate chain 2; dynein, cytoplasmic, intermediate polypeptide 2; IC2; oncofetal protein (OFP); testis tissue sperm-binding protein Li 66n
Gene Symbols DYNC1I2
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of human DYNC1I2. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 13427, 1781
Target Species Human, Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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