DYNC1I2 Rabbit anti-Human, Mouse, Polyclonal, Bethyl Laboratories

Catalog No.	Quantity
50-156-7955	100 μL

Catalog No. 50-156-7955 Supplier Bethyl Laboratories, Inc Supplier No. A304529A

Description

Rabbit Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt. Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections. Based on 100% sequence identity, this antibody is predicted to react with Rat, Bovine and Orangutan

Dyneins are multi-subunit, high molecular weight ATPases that interact with microtubules to generate force by converting the chemical energy of ATP into the mechanical energy of movement. Cytoplasmic or axonemal Dynein heavy, intermediate, light and light-intermediate chains are all components of minus end-directed motors; the complex that transports cellular cargos towards the central region of the cell. Axonemal Dynein motors contain one to three non-identical heavy chains and cause a sliding of microtubules in the axonemes of cilia and flagella in a mechanism necessary for cilia to beat and propel the cell. Cytoplasmic Dynein is an approximately 12 subunit complex of two heavy chains, two intermediate chains to anchor Dynein to its cargo, four smaller intermediate chains and several light chains. It performs functions necessary for cell survival such as organelle transport and centrosome assembly. The carboxy-terminus of Dynein is important for microtubule-dependent motility and is highly conserved, while the amino-terminal regions are more variable. Several proteins regulate Dynein activity, including Dynactin, LIS1 and nudel (nudE-like).

Specifications

• Antigen: DYNC1I2
• Applications: Immunohistochemistry, Immunoprecipitation, Western Blot
• Classification: Polyclonal
• Concentration: 1 mg/ml
• Conjugate: Unconjugated
• Formulation: phosphate, tris citrate with 0.09% sodium azide; pH 7-8
• Gene: DYNC1I2
• Gene Accession No.: O88487, Q13409
• Gene Alias: DNCI2, IC2, DH IC-2, cytoplasmic dynein 1 intermediate chain 2, cytoplasmic dynein intermediate chain 2, dynein intermediate chain 2, cytosolic, dynein, cytoplasmic, intermediate polypeptide 2
• Gene Symbols: DYNC1I2
• Host Species: Rabbit
• Immunogen: Between 588 and 638
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 13427, 1781
• Target Species: Human, Mouse
• Content And Storage: 4° C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG