Invitrogen™ DYNLT1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5103810

Catalog No. PIPA5103810

Description

Antibody detects endogenous levels of total DYNLT1.

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Binds to transport cargos and is involved in apical cargo transport such as rhodopsin-bearing vesicles in polarized epithelia. Is involved in intracellular targeting of D-type retrovirus gag polyproteins to the cytoplasmic assembly site. May also be a accessory component of axonemal dynein. Plays a role in neuronal morphogenesis; the function is independent of cytoplasmic dynein and seems to be coupled to regulation of the actin cytoskeleton by enhancing Rac1 activity. The function in neurogenesis may be regulated by association with a G-protein beta-gamma dimer. May function as a receptor-independent activator of heterotrimeric G-protein signaling; the activation appears to be independent of a nucleotide exchange. Plays a role in regulating neurogenesis; inhibits the genesis of neurons from precursor cells during cortical development presumably by antagonizing ARHGEF2. Involved in the regulation of mitotic spindle orientation.

Specifications

• Antigen: DYNLT1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: DYNLT1
• Gene Alias: activator of G-protein signaling 2; AGS2; CW-1; Dynein light chain Tctex-type 1; dynein light chain Tctex-type 1B; dynein light chain Tctex-type 1D; dynein, light chain, Tctex-type 1; Dynlt1; Dynlt1b; Protein CW-1; t-complex testis expressed 1; T-complex testis-specific protein 1; T-complex testis-specific protein 1 homolog; t-complex-associated-testis-expressed 1-like 1; TCTEL1; Tctex1; Tctex-1
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 6993
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: P63172
• Gene Symbols: DYNLT1
• Immunogen: A synthesized peptide derived from human DYNLT1(Accession P63172), corresponding to amino acid residues M1-G31.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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