Invitrogen™ DYRK1A Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA514490

Catalog No. PIPA514490

Description

This antibody is predicted to react with mouse, rat and Xenopus based on sequence homology.

DYRK1A is a dual specificity kinase involved in cell proliferation. The gene for DYRK1A is located in the Down syndrome critical region of chromosome 21, and has been implicated in the pathogenesis of this disease. DYRK1A catalyzes the transition of 3-phosphoglycerate into 3-phosphohydroxypyruvate, which is the first and rate-limiting step in the phosphorylated pathway of serine biosynthesis, using NAD+/NADH as a cofactor.

Specifications

• Antigen: DYRK1A
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: DYRK1A
• Gene Alias: 2310043O08Rik; D16Ertd272e; D16Ertd493e; dual specificity tyrosine phosphorylation regulated kinase 1A; dual specificity tyrosine-(Y)-phosphorylation regulated kinase 1A; dual specificity tyrosine-phosphorylation-regulated kinase 1A; Dual specificity YAK1-related kinase; dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a; Dyrk; DYRK1; Dyrk1a; ENSMUSG00000074897; Gm10783; hMNB; HP86; mmb; MNB; mnb protein kinase homolog hp86; MNB/DYRK protein kinase; MNBH; MP86; MRD7; OTTHUMP00000109090; Protein kinase minibrain homolog; PSK47; RP86; serine/threonine kinase MNB; serine/threonine-specific protein kinase
• Host Species: Rabbit
• Purification Method: Ammonium sulfate precipitation, Size-exclusion - Dialysis
• Regulatory Status: RUO
• Gene ID (Entrez): 13548, 1859
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 2.0 mg/mL
• Formulation: PBS with 0.09% sodium azide; pH 7.4
• Gene Accession No.: Q13627, Q61214
• Gene Symbols: DYRK1A
• Immunogen: KLH conjugated synthetic peptide between 107-136 amino acids from the N-terminal region of human DYRK1A.
• Quantity: 400 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG