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DYRK2 Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501982149
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50-198-2149 100 μL
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Catalog No. 50-198-2149 Supplier Bioss Supplier No. BS12332R
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Description

Rabbit Polyclonal Antibody

DYRK2, or dual specificity tyrosine-phosphorylation-regulated kinase 2, has a role in the regulation of cellular growth and/or development. In response to DNA damage, DYRK2 regulates p53 phosphorylation on Ser-46 to induce apoptosis. DYRK2 has been proposed to inactivate GYS1 by phosphorylation at Ser-641, and potentially a second phosphorylation site, thus regulating glycogen synthesis. DYRK2 also phosphorylates EIF2B5 at Ser-544, enabling its subsequent phosphorylation and inhibition by GSK3, and may play a more general role in the priming of GSK3 substrates.

Specifications

Antigen DYRK2
Applications Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene DYRK2
Gene Accession No. Q92630
Gene Alias 1810038L18Rik; dual specificity tyrosine phosphorylation regulated kinase 2; dual specificity tyrosine-(Y)-phosphorylation regulated kinase 2; Dual specificity tyrosine-phosphorylation-regulated kinase 2; dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2; Dyrk2
Gene Symbols DYRK2
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide derived from human DYRK2.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 8445
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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