Invitrogen™ DYRK3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA521875

Catalog No. PIPA521875

Description

Recommended positive controls: 293T, H1299, HepG2, Raji, mouse liver. Predicted reactivity: Mouse (92%), Rat (94%), Chimpanzee (99%), Bovine (95%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

DYRK3 belongs to the DYRK family of dual-specificity protein kinases that catalyze phosphorylation of serine/threonine and tyrosine residues. The members of this family share structural similarity, but differ in their substrate specificity, suggesting their involvement in different cellular functions. DYRK3 is a negative regulator of EPO-dependent erythropoiesis, may place an upper limit on red cell production during stress erythropoiesis. Inhibits cell death due to cytokine withdrawal in hematopoietic progenitor cells. May act by regulating CREB/CRE signaling.

Specifications

• Antigen: DYRK3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: DYRK3
• Gene Alias: BC006704; dual specificity tyrosine phosphorylation regulated kinase 3; dual specificity tyrosine-(Y)-phosphorylation regulated kinase 3; dual specificity tyrosine-phosphorylation-regulated kinase 3; dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3; dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 5; dyrk3; dyrk3 {ECO:0000312; DYRK5; EMBL:AAH97474.1}; hYAK3-2; KSR; protein kinase Dyrk3; RED; REDK; regulatory erythroid kinase; RP11-343H5.2; RSU2
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 226419, 8444
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.68 mg/mL
• Formulation: 0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: O43781, Q922Y0
• Gene Symbols: DYRK3
• Immunogen: Recombinant protein encompassing a sequence within the center region of human Dyrk3. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG