Invitrogen™ Dysadherin Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA552747

Catalog No. PIPA552747

Description

Immunogen sequence: DTTSSSSADS TIMDIQVPTR APDAVYTELQ PTSPTPTWPA DETPQPQTQT QQLEGTDGPL VTDPETHKST KAAHPTDDTT TLSERPSPST DVQTDPQTLK PSGFHEDDPF FYDEHTLR Highest antigen sequence identity to the following orthologs: Mouse - 33%, Rat - 31%.

This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 in variant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. This gene product, FXYD5, is a glycoprotein that functions in the up-regulation of chemokine production, and it is involved in the reduction of cell adhesion via its ability to down-regulate E-cadherin. It also promotes metastasis, and has been linked to a variety of cancers. Alternative splicing results in multiple transcript variants.

Specifications

• Antigen: Dysadherin
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: FXYD5
• Gene Alias: DYSAD; Dysadherin; EF-8; FXYD domain containing ion transport regulator 5; FXYD domain-containing ion transport regulator 5; FXYD5; HSPC113; Ion channel homolog RIC; IWU1; IWU-1; KCT1; keratinocytes associated transmembrane protein 1; OIT2; oncoprotein induced transcript 2; oncoprotein-induced protein 2; PRO6241; RIC; UNQ2561/PRO6241
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 53827
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.2 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q96DB9
• Gene Symbols: FXYD5
• Immunogen: Recombinant protein corresponding to Human Dysadherin. Recombinant protein control fragment (Product #RP-90023).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG