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Invitrogen™ E-cadherin Monoclonal Antibody (7A2)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA515717

Catalog No. PIMA515717


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Description

Description

MA5-15717 targets CDH1 in indirect ELISA, WB applications and shows reactivity with Human, mouse, and Non-human primate samples. The MA5-15717 immunogen is purified recombinant fragment of human CDH1 expressed in E. Coli. MA5-15717 detects CDH1 which has a predicted molecular weight of approximately 135kDa.

E-Cadherin (epithelial cadherin) is a classical cadherin from the cadherin (alcium dependent adhesion protein) superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. E-cadherin plays a central role in the growth and development of cells by controlling tissue architecture, and maintenance of tissue integrity. In humans, E-cadherin is encoded by the CDH1 gene present on chromosome 16. Studies have demonstrated that reduction and/or loss of E-cadherin expression in carcinomas correlates positively with the potential of these tumors for invasion and metastasis.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

E-cadherin
Monoclonal
Conc. Not Determined
ascites with 0.03% sodium azide
P09803, P12830, Q9R0T4
CDH1
Purified recombinant fragment of human CDH1 expressed in E. Coli.
RUO
12550, 83502, 999
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Liquid
ELISA, Western Blot
7A2
Unconjugated
CDH1
AA960649; ARC-1; cadherin 1; cadherin 1, E-cadherin (epithelial); cadherin 1, epithelial; cadherin 1, type 1; cadherin 1, type 1, E-cadherin (epithelial); cadherin e; cadherin-1; cadherin-E; calcium-dependent adhesion protein, epithelial; CAM 120/80; CD324; CDH1; CDHE; cell adhesion molecule; cell-CAM 120/80; ECAD; E-cad; E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3; Ecadherin; E-cadherin; E-cadherin 1; E-cadherin precursor; Epithelial cadherin; hab; half baked; LCAM; L-CAM; Um; UVO; Uvomorulin
Mouse
100 μL
Primary
Human, Mouse, Rat, Monkey
Antibody
IgG1
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