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Invitrogen™ E-cadherin Monoclonal Antibody (7H12)
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Catalog No. PIMA515711
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100 μL
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Catalog No. Quantity
PIMA515711 100 μL
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Catalog No. PIMA515711 Supplier Invitrogen™ Supplier No. MA515711
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Description

Mouse Monoclonal Antibody

MA5-15711 targets CDH1 in indirect ELISA, FACS, IHC, and WB applications and shows reactivity with Human, mouse, and Non-human primate samples. The MA5-15711 immunogen is purified recombinant fragment of human CDH1 expressed in E. Coli. MA5-15711 detects CDH1 which has a predicted molecular weight of approximately 135kDa.

E-Cadherin (epithelial cadherin) is a classical cadherin from the cadherin (alcium dependent adhesion protein) superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. E-cadherin plays a central role in the growth and development of cells by controlling tissue architecture, and maintenance of tissue integrity. In humans, E-cadherin is encoded by the CDH1 gene present on chromosome 16. Studies have demonstrated that reduction and/or loss of E-cadherin expression in carcinomas correlates positively with the potential of these tumors for invasion and metastasis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen E-cadherin
Applications ELISA, Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone 7H12
Concentration Conc. Not Determined
Conjugate Unconjugated
Formulation Ascites with 0.03% sodium azide
Gene CDH1
Gene Accession No. P09803, P12830
Gene Alias AA960649; ARC-1; cadherin 1; cadherin 1, E-cadherin (epithelial); cadherin 1, epithelial; cadherin 1, type 1; cadherin 1, type 1, E-cadherin (epithelial); cadherin e; cadherin-1; cadherin-E; calcium-dependent adhesion protein, epithelial; CAM 120/80; CD324; CDH1; CDHE; cell adhesion molecule; cell-CAM 120/80; ECAD; E-cad; E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3; Ecadherin; E-cadherin; E-cadherin 1; E-cadherin precursor; Epithelial cadherin; hab; half baked; LCAM; L-CAM; Um; UVO; Uvomorulin
Gene Symbols CDH1
Host Species Mouse
Immunogen Purified recombinant fragment of human CDH1 expressed in E. Coli.
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 12550, 999
Target Species Human, Mouse, Monkey
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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