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E-cadherin Monoclonal Antibody (DH01 (DCS-266)), Invitrogen™

Catalog No. PIMA511496
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500 μL
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Catalog No. Quantity
PIMA511496 500 μL
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Catalog No. PIMA511496 Supplier Thermo Scientific Supplier No. MA511496

Description

Mouse Monoclonal Antibody

MA5-11496 targets APC/C activator protein CDH1 in IP, ICC/IF and WB applications and shows reactivity with Human samples. The MA5-11496 immunogen is recombinant human cdh1 protein.

E-Cadherin (epithelial cadherin) is a classical cadherin from the cadherin (alcium dependent adhesion protein) superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. E-cadherin plays a central role in the growth and development of cells by controlling tissue architecture, and maintenance of tissue integrity. In humans, E-cadherin is encoded by the CDH1 gene present on chromosome 16. Studies have demonstrated that reduction and/or loss of E-cadherin expression in carcinomas correlates positively with the potential of these tumors for invasion and metastasis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen E-cadherin
Applications Immunocytochemistry, Immunoprecipitation, Western Blot
Classification Monoclonal
Clone DH01 (DCS-266)
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.2% BSA and 0.09% sodium azide; pH 7.4
Gene CDH1
Gene Accession No. P12830
Gene Alias AA960649; ARC-1; cadherin 1; cadherin 1, E-cadherin (epithelial); cadherin 1, epithelial; cadherin 1, type 1; cadherin 1, type 1, E-cadherin (epithelial); cadherin e; cadherin-1; cadherin-E; calcium-dependent adhesion protein, epithelial; CAM 120/80; CD324; CDH1; CDHE; cell adhesion molecule; cell-CAM 120/80; ECAD; E-cad; E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3; Ecadherin; E-cadherin; E-cadherin 1; E-cadherin precursor; Epithelial cadherin; hab; half baked; LCAM; L-CAM; Um; UVO; Uvomorulin
Gene Symbols CDH1
Host Species Mouse
Immunogen Recombinant human cdh1 protein
Purification Method Protein G
Quantity 500 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 999
Target Species Human
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG1 κ
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