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E-cadherin Polyclonal Antibody, Invitrogen™

Catalog No. PIPA580457
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100 μL
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PIPA580457 100 μL
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Catalog No. PIPA580457 Supplier Thermo Scientific Supplier No. PA580457

Description

Rabbit Polyclonal Antibody

This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%). This antibody has specificity for Human E-Cadherin/CDH1/E-cad/CD324.

E-Cadherin (epithelial cadherin) is a classical cadherin from the cadherin (alcium dependent adhesion protein) superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. E-cadherin plays a central role in the growth and development of cells by controlling tissue architecture, and maintece of tissue integrity. In humans, E-cadherin is encoded by the CDH1 gene present on chromosome 16. Studies have demonstrated that reduction and/or loss of E-cadherin expression in carcinomas correlates positively with the potential of these tumors for invasion and metastasis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen E-cadherin
Applications ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Conjugate Unconjugated
Formulation PBS with no preservative
Gene CDH1
Gene Accession No. P12830
Gene Alias Arc-1, CD324, CDHE, ECAD, LCAM, UVO, CAM 120/80, E-Cadherin, cadherin 1, E-cadherin epithelial, cadherin-1, calcium-dependent adhesion protein, epithelial, cell-CAM 120/80, epithelial cadherin, uvomorulin, cadherin-E
Gene Symbols CDH1
Host Species Rabbit
Immunogen Recombit Human E-Cadherin/CDH1/E-cad/CD324 protein
Purification Method Antigen Affinity Chromatography, Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 999
Target Species Human
Content And Storage Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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