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Invitrogen™ E-selectin Monoclonal Antibody (1.2B6)
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Catalog No. PIMA122165
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100 μg
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Catalog No. Quantity
PIMA122165 100 μg
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Catalog No. PIMA122165 Supplier Invitrogen™ Supplier No. MA122165
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Description

Mouse Monoclonal Antibody

Not suitable for immunohistochemistry (paraffin). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Leukocytes adhere to the blood vessel endothelium during extravasation in postcapillary venules of lymph nodes. In addition, leukocyte adhesion occurs in the capillaries and small venules at any site in the body after onset of inflammation. This response is immediate and involves a cascade of adhesion receptors. At the endothelial surface members of the selectin and immunoglobulin superfamilies participate in this cascade. Selectins are C-type cell surface lectins that play a role in leukocyte adhesion to the blood vessel wall endothelium. E-selectin (CD62E) is an endothelial cell specific selectin that is expressed only after activation with proinflammatory cytokines. In vitro experiments have shown that IL-1, TNFalpha and bacterial wall components like lipopolysaccharides induce the transcription of E-selectin in a NFkB dependent signaling cascade. E-selectin has been associated with blood vessel endothelium in diverse inflammatory situations.
TRUSTED_SUSTAINABILITY

Specifications

Antigen E-selectin
Applications ELISA, Flow Cytometry, Immunohistochemistry (Frozen), Immunoprecipitation, Western Blot, Immunocytochemistry
Classification Monoclonal
Clone 1.2B6
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.09% sodium azide
Gene SELE
Gene Accession No. P16581, P98110
Gene Alias CD62 antigen-like family member E; CD62E; e selectin; Elam; ELAM1; ELAM-1; endothelial adhesion molecule 1; endothelial leukocyte adhesion molecule; endothelial leukocyte adhesion molecule 1; endothelial leukocyte adhesion molecule I; ESEL; E-selectin; LECAM2; leukocyte endothelial cell adhesion molecule 2; leukocyte-endothelial cell adhesion molecule 2; RP1-117P20.2; SELE; selectin E; selectin E (endothelial adhesion molecule 1); selectin, endothelial cell
Gene Symbols SELE
Host Species Mouse
Immunogen Human E-Selectin (ELAM-1).
Purification Method Protein A
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 397508, 6401
Target Species Human, Pig
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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