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Invitrogen™ E-selectin Monoclonal Antibody (ENA1)
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Catalog No. FERMA549105
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100 μg
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Catalog No. Quantity
FERMA549105 100 μg
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Catalog No. FERMA549105 Supplier Invitrogen™ Supplier No. MA549105
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Description

Mouse Monoclonal Antibody

ENA1 reacts with E-selectin CD62-E, previous designated the Endothelial Leucocyte Adhesion Molecule-1 (ELAM-1). The antibody reacts with human endothelial cells activated with TNF-alpha, IL-1 or endotoxin. The antibody was found to react also with cells transfected with the E-selectin gene. The antibody inhibits the adhesion of granulocytes both neutrophilic and eosinophilic.

Leukocytes adhere to the blood vessel endothelium during extravasation in postcapillary venules of lymph nodes. In addition, leukocyte adhesion occurs in the capillaries and small venules at any site in the body after onset of inflammation. This response is immediate and involves a cascade of adhesion receptors. At the endothelial surface members of the selectin and immunoglobulin superfamilies participate in this cascade. Selectins are C-type cell surface lectins that play a role in leukocyte adhesion to the blood vessel wall endothelium. E-selectin (CD62E) is an endothelial cell specific selectin that is expressed only after activation with proinflammatory cytokines. In vitro experiments have shown that IL-1, TNFalpha and bacterial wall components like lipopolysaccharides induce the transcription of E-selectin in a NFkB dependent signaling cascade. E-selectin has been associated with blood vessel endothelium in diverse inflammatory situations.
TRUSTED_SUSTAINABILITY

Specifications

Antigen E-selectin
Applications Functional Assay, Inhibition Assays, Immunohistochemistry (Frozen), Immunoprecipitation
Classification Monoclonal
Clone ENA1
Concentration 100 μg/mL
Conjugate Unconjugated
Formulation PBS with 0.1% BSA and no preservative
Gene SELE
Gene Accession No. P16581
Gene Alias CD62 antigen-like family member E; CD62E; e selectin; Elam; ELAM1; ELAM-1; endothelial adhesion molecule 1; endothelial leukocyte adhesion molecule; endothelial leukocyte adhesion molecule 1; endothelial leukocyte adhesion molecule I; ESEL; E-selectin; LECAM2; leukocyte endothelial cell adhesion molecule 2; leukocyte-endothelial cell adhesion molecule 2; RP1-117P20.2; SELE; selectin E; selectin E (endothelial adhesion molecule 1); selectin, endothelial cell
Gene Symbols SELE
Host Species Mouse
Immunogen ENA1 reacts with E-selectin CD62-E.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 6401
Target Species Human
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG1
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